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However, several species - including humans, non-human primates, guinea pigs, Indian fruit bats, and Nepalese red-vented bulbuls - are unable to synthesise vitamin C. When there is insufficient vitamin C in the diet, humans suffer from the potentially lethal deficiency disease scurvy (1). Three of those enzymes are found in fungi but not in humans or other mammals (5, 6). They are involved in reutilisation pathways for pyrimidines and the deoxyribose moiety of deoxynucleosides. In the hypothalamus, oxytocin is made in magnocellular neurosecretory cells of the supraoptic and paraventricular nuclei, and is stored in Herring bodies at the axon terminals in the posterior pituitary.It is then released into the blood from the posterior lobe (neurohypophysis) of the pituitary gland.The time frame selected for the current systematic review was from the year 1952-2014.

Enzymatic functions Vitamin C acts as an electron donor for 11 enzymes (3, 4).

Descriptive Table of Vertebrate Hormones Structure and Function of Hormones Receptors for Peptide Hormones Basics of Peptide Hormones The Hypothalamic-Pituitary Axis The Glycoprotein Hormone Family The Gonadotropins (LH, FSH, h CG) Thyroid Stimulating Hormone (TSH) Pro-Opiomelanocortin (POMC) Family Adrenocorticotropic Hormone, ACTH POMC-Derived Melanocortins & Feeding Behavior The Posterior Pituitary Hormones Vasopressin and Oxytocin The Growth Hormone Family Growth Hormone (GH) Human Chorionic Somatomammotropin (h CS) Prolactin (PRL) The Pancreatic Polypeptide Family: PP, PYY, NPY Melanin-Concentrating Hormone, MCH The Orexins Gastrointestinal Hormones and Peptides Adipose Tissue Hormones and Cytokines Irisin: Exercise-Induced Skeletal Muscle Hormone Natriuretic Hormones Renin-Angiotensin System Parathyroid Hormone (PTH) Calcitonin Family Erythropoietin, EPO The Pancreatic Hormones Insulin and Glucagon Somatostatin Amylin The integration of body functions in humans and other higher organisms is carried out by the nervous system, the immune system, and the endocrine system.

The endocrine system is composed of a number of tissues that secrete their products, endocrine hormones, into the circulatory system; from there they are disseminated throughout the body, regulating the function of distant tissues and maintaining homeostasis.

Humans and primates lack the terminal enzyme in the biosynthetic pathway of ascorbic acid, l-gulonolactone oxidase, because the gene encoding for the enzyme has undergone substantial mutation so that no protein is produced (2).

Background biochemistry Vitamin C is an electron donor (reducing agent or antioxidant), and probably all of its biochemical and molecular functions can be accounted for by this function.




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